Isuzu Motors Ltd. (Japanese: いすゞ自動車株式会社 Hepburn: Isuzu Jidōsha Kabushiki-Kaisha, TYO: 7202), trading as Isuzu (Japanese pronunciation: [isɯzɯ], /iˈsuːzuː/), is a Japanese commercial vehicle and diesel engine manufacturing company headquartered in Tokyo. Its principal activity is the production, marketing and sale of Isuzu commercial vehicles and diesel engines.

It also has a number of subsidiaries, including Anadolu Isuzu (a Turkish joint venture with Anadolu Group), Sollers-Isuzu (a Russian joint venture with Sollers JSC), SML Isuzu (an Indian venture formerly known as Swaraj Mazda), Jiangxi Isuzu Motors (a Chinese joint venture with Jiangling Motors Company Group), Isuzu Astra Motor Indonesia, Isuzu Malaysia (Isuzu HICOM), Isuzu UK, Isuzu South Africa, Isuzu Philippines, Taiwan Isuzu Motors, Isuzu Vietnam, Isuzu Motors India and BYD Isuzu.

Isuzu has assembly and manufacturing plants in Fujisawa, as well as in the Tochigi and Hokkaidō prefectures. Isuzu-branded vehicles are sold in most commercial markets worldwide. Isuzu's primary market focus is on commercial diesel-powered truck, buses and construction, while their Japanese competitor Yanmar focuses on commercial-level powerplants and generators.

By 2009, Isuzu had produced over 21 million diesel engines, which can be found in vehicles all over the world. Isuzu diesel engines are used by dozens of vehicle manufacturers, including General Motors.[citation needed]

The name Isuzu translates into English as "fifty bells".

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